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Two Hippo signaling modules orchestrate liver size and tumorigenesis. Qi S, Zhong Z, Zhu Y, Wang Y, Ma M, Wang Y, Liu X, Jin R, Jiao Z, Zhu R, Sha Z, Dang K, Liu Y, Lim DS, Mao J, Zhang L, Yu FX. (2023) The EMBO Journal. Mar 15:e112126.

Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers. Gu Y, Wang Y, Sha Z, He C, Zhu Y, Li J, Yu A, Zhong Z, Wang X, Sun Y, Lan F, Yu FX. (2022) Cell Reports. Aug 30;40(9):111296.

WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy. Qi S, Zhu Y, Liu X, Li P, Wang Y, Zeng Y, Yu A, Wang Y, Sha Z, Zhong Z, Zhu R, Yuan H, Ye D, Huang S, Ling C, Xu Y, Zhou D, Zhang L, Yu FX. (2022) Molecular Cell. Apr 8:S1097-2765(22)00265-9.

Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis. Wang Y, Zhu Y, Gu Y, Ma M, Wang Y, Qi S, Zeng Y, Zhu R, Wang X, Yu P, Xu J, Shu Y, Yu FX. (2021) Cell Reports. Aug 24;36(8):109596.

Nelfinavir inhibits human DDI2 and potentiates cytotoxicity of proteasome inhibitors. Gu Y, Wang X, Wang Y, Wang Y, Li J, Yu FX. (2020) Cell Signal. Nov;75:109775.

Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma. Li Y, Li J, Wang R, Zhang L, Fu G, Wang X, Wang Y, Fang C, Zhang D, Du D, Ma X, Pan M, Guo Q, Xu X, Hu X, Zhou Y, Mo S, Wang H, Gao J, Huang S, Liu Y, Cai S, Hua G*, Peng J*, Yu FX*. (2020) Protein Cell. Apr;11(4):292-298.

USP47-mediated deubiquitination and stabilization of YAP contributes to the progression of colorectal cancer. Pan B, Yang Y, Li J, Wang Y, Fang C, Yu FX*,Xu Y*. (2020) Protein Cell. Feb;11(2):138-143.

An alternatively transcribed TAZ variant negatively regulates JAK-STAT signaling. Fang C, Li J, Qi S, Lei Y, Zeng Y, Yu P, Hu Z, Zhou Y, Wang Y, Dai R, Li J, Huang S, Xu P, Chen K, Ding C, Yu FX. (2019) EMBO Reports. Jun;20(6). pii: e47227.

RAP2 mediates mechanoresponses of the Hippo pathway. Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, Park HW, Wang X, Yu FX, Chien S, Wang CY, Ren B, Engler AJ, Guan KL. (2018) Nature. Aug;560(7720):655-660.

The Hippo pathway in tissue homeostasis and regeneration. Wang Y, Yu A, Yu FX. (2017) Protein Cell. May;8(5):349-359. Review.

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. Yu FX*, Zhao B, Guan KL*. (2015) Cell. Nov 5;163(4):811-28.(Leading Edge Review)

Opposing roles of conventional and novel PKC isoforms in Hippo-YAP pathway regulation. Gong R, Hong AW, Plouffe SW, Zhao B, Liu G, Yu FX*, Xu Y*, Guan KL*. (2015) Cell Res. Aug;25(8):985-8.

Alternative Wnt Signaling Activates YAP/TAZ. Park HW, Kim YC, Yu B, Moroishi T, Mo JS, Plouffe SW, Meng Z, Lin KC, Yu FX, Alexander CM, Wang CY, Guan KL. (2015) Cell. Aug 13;162(4):780-94.

A gp130-Src-YAP module links inflammation to epithelial regeneration. Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M. (2015) Nature. Mar 5;519(7541):57-62.

Differential regulation of mTORC1 by leucine and glutamine. Jewell JL, Kim YC, Russell RC, Yu FX, Park HW, Plouffe SW, Tagliabracci VS, Guan KL. (2015) Science. Jan 9;347(6218):194-8.

Hippo pathway regulation of gastrointestinal tissues. Yu FX, Meng Z, Plouffe SW, Guan KL. (2015) Annu Rev Physiol. 77:201-27.

Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Yu FX, Luo J, Mo JS, Liu G, Kim YC, Meng Z, Zhao L, Peyman G, Ouyang H, Jiang W, Zhao J, Chen X, Zhang L, Wang CY, Bastian BC, Zhang K, Guan KL. (2014) Cancer Cell. Jun 16;25(6):822-30. (Fox News, Scientists discover how two gene mutations cause melanoma of the eye)

Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway. Liu G, Yu FX, Kim YC, Meng Z, Naipauer J, Looney DJ, Liu X, Gutkind S, Mesri EA, Guan KL. (2015) Oncogene. Jul;34(27):3536-46.

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Yu FX, Zhang Y, Park HW, Jewell JL, Chen Q, Deng Y, Pan D, Taylor SS, Lai ZC, Guan KL. (2013) Genes Dev. 2013 Jun 1;27(11):1223-32.

The Hippo pathway: regulators and regulations. Yu FX, Guan KL. (2013) Genes Dev. Feb 15;27(4):355-71.

Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Yu FX, Zhao B, Panupinthu N, Jewell JL, Lian I, Wang LH, Zhao J, Yuan H, Tumaneng K, Li H, Fu XD, Mills GB, Guan KL. (2012) Cell. Aug 17;150(4):780-91. (Cell, Best of 2012 in Cell; Sci. Signal, 2012 Signaling Breakthroughs of the Year)

A potential mechanism of metformin-mediated regulation of glucose homeostasis: inhibition of Thioredoxin-interacting protein (Txnip) gene expression. Chai TF, Hong SY, He H, Zheng L, Hagen T, Luo Y*, Yu FX*. (2010) Cell Signal. Aug;24(8):1700-5.

Thioredoxin-interacting protein (Txnip) gene expression: sensing oxidative phosphorylation status and glycolytic rate. Yu FX, Chai TF, He H, Hagen T, Luo Y. (2010) J Biol Chem. Aug 13;285(33):25822-30.

Tandem ChoRE and CCAAT motifs and associated factors regulate Txnip expression in response to glucose or adenosine-containing molecules. Yu FX, Luo Y. (2009) PLoS One. Dec 22;4(12):e8397.

Adenosine-containing molecules amplify glucose signaling and enhance txnip expression. Yu FX, Goh SR, Dai RP, Luo Y. (2009) Mol Endocrinol. Jun;23(6):932-42.